Ankylosing spondylitis treatment pdf

Find ankylosing spondylitis treatment pdf resources in the Cochrane Community. They found 21 trials with 3308 participants. Most studies were funded by pharmaceutical companies. What is ankylosing spondylitis and what are anti-TNF drugs?

Ankylosing spondylitis is a type of arthritis, usually in the joints and ligaments of the spine, but it may also affect other joints. Pain and stiffness occurs and limits movement in the back and affected joints. It can come and go, last for long periods, and be quite severe. Anti-TNF drugs target a protein called ‘tumor necrosis factor’ that causes inflammation. These drugs suppress the immune system and reduce the inflammation in the joints, with the aim of preventing damage. Even though suppressing the immune system can make it slightly harder to fight off infections, it also helps to stabilize an overactive immune system.

In the broader healthcare context it refers to any attempt to synthesise the results of more than one study on a particular topic area. We do not have precise information about side effects and complications, but in these short-term studies there was no evidence of an increase in serious adverse events. Rare complications may include certain types of cancer. An intervention that to all intents and purposes appears to be the same as that which is being assessed but which does not have the active component being assessed.

A systematic, well-planned investigation of a healthcare problem. Data is the information collected through research. It can include written information, numbers, sounds and pictures. It is usually stored on computer, so that it can be analysed, interpreted and then communicated to others, for example in reports, graphs or diagrams. There may be little or no difference in the number of people who have a serious side effect with an anti-TNF drug compared to people who take a fake pill. There is moderate to high quality evidence that anti-TNF agents improve clinical symptoms in the treatment of ankylosing spondylitis.

More participants withdrew due to adverse events when on an anti-TNF agent but we did not find evidence of an increase in serious adverse events, though event rates were low and trials had a short duration. The degree or strength of a poison. Based on indirect comparison methodology, we are uncertain whether there are differences between anti-TNF agents in terms of the key benefit or harm outcomes. An American based electronic database listing articles of biomedical research from a pre-determined range of peer-reviewed publications. We searched major regulatory agencies for safety warnings and clinicaltrials.

A brief, clearly structured summary of the main features and results of a study. A way of expressing the chance of an event taking place, expressed as the number of events divided by the total number of observations or people. This measure is good no matter the incidence of events ie common or infrequent. Any factor, recognised or not, that distorts the findings of a study.

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